Cationic Quaternized Chitosan Nanoparticles for C-phycocyanin Delivery to Hela Cells

Peng Yang, Bing Li, Cong-Yi Lv, Qi-Feng Yin and Yu-Juan Wang

International Journal of Sciences, 2015, vol. 4, issue 09, 17-23

Abstract: In this study we synthesize C-PC/QAC nanoparticles using cationic quaternary ammonium chitosan (QAC) as substrate material loaded C-phycocyanin (C-PC) by ionic-gelation method. The prepared NPs was about 120nm size with spherical morphology, the entrapment efficient was 62%, and the drug-loading amount was 20%. The NPs exhibited a pH sensitive realease of C-PC in vitro. The drug-NPs were proved to be hemocompatible and safe. In conclusion, QAC increased bioavailability and anticancer property of C-PC.

Keywords: Cancer Therapy; Drug Delivery; C-phycocyanin·Quaternary; Ammonium Chitosan; Nanoparticles (search for similar items in EconPapers)
Date: 2015
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DOI: 10.18483/ijSci.834

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