Addition of Exogenous α-Synuclein Oligomer up-regulates Divalent Metal Transporter-1 and Ferroportin-1 in BV2 Glial Cell Lines

Chengkui Shi and Xinxing Du

International Journal of Sciences, 2016, vol. 5, issue 11, 54-60

Abstract: It has been confirmed that α-synuclein (α-syn) aggregation in neurons or glia and formation of Lewybodies is the remarked pathognomonic hallmark of PD. Neuropathology study have found α-Syn in abnormal aggregation often accompany with iron deposits. At present ,a lot of research confirmed that divalent metal transporter 1(DMT1), is up-regulated and ferroportin-1 is downregulated in the SN of PD and accumulate of iron in this region.Therefore understanding exogenous α-Syn oligomer whether arise this phenomenon in BV2 glial cell lines is necessary.

Keywords: Microglia cell; α-Synuclein oligomer; Iron; Membrance Transport Proteins (search for similar items in EconPapers)
Date: 2016
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DOI: 10.18483/ijSci.1147

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