Ghrelin/GHS-R1a Signaling Modulates Emotional Learning and Memory

Nan Li

International Journal of Sciences, 2016, vol. 5, issue 03, 160-163

Abstract: The amygdala complex is strongly involved in the formation of emotional memories, and GHS-R1a was found to be highly expressed in the lateral amygdala versus the central nucleus. Our previous study showed that micro-injection of ghrelin, the natural ligand of GHS-R1a, into lateral amygdala impairs memory in mice. Consistently, GHS-R1a KO mice shows enhanced memory. To explore the cellular mechanism mediating the effect of GHS-R1a signaling on emotional memory, we recorded spontaneous IPSCs and EPSCs in GHS-R1a KO and WT BL6 control mice. We found that GHS-R1a KO mice exhibited higher amplitude of IPSCs compared to that of control mice, while the EPSC We found that GHS-R1a KO mice exhibited higher frequency compared to that of control mice.

Keywords: Ghrelin; GHS-R1a; emotional learning; emotional memory (search for similar items in EconPapers)
Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.ijsciences.com/pub/article/993 (text/html)
https://www.ijsciences.com/pub/pdf/V5201603993.pdf (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adm:journl:v:5:y:2016:i:3:p:160-163

Ordering information: This journal article can be ordered from
https://www.ijsciences.com/payment_guide.php

DOI: 10.18483/ijSci.993

Access Statistics for this article

More articles in International Journal of Sciences from Office ijSciences Alkhaer Publications Manchester M8 8XG England.
Bibliographic data for series maintained by Staff ijSciences ().