Effects of Iron Overload on Growth and Intestinal Mucosa in Rats

Yi-chen Jiang, Yong-ye Sun, Wei-lei Gong, Yuan-yuan Li and Ai-guo Ma

International Journal of Sciences, 2017, vol. 6, issue 03, 57-61

Abstract: Objective: To detect the mechanism of excess iron intake on growth and intestinal mucosa in rats. Methods: Forty-eight male Wistar rats were randomly divided into four groups: Low Iron Group, Normal Iron Group, Medium Iron Group and High Iron Group upon daily iron intake of 7mg/kg, 16.8mg/kg, 35mg/kg, 70mg/kg respectively via fodder for eight weeks. The general condition, body weight and food intake were documented simultaneously. Serum level of Ferritin, IL-6 and IL-10 were detected using ELISA. The observation of morphology of intestine was also included concurrently. Results: The weight obtained was significantly lower in the High Iron Group compared with the other three groups while the average weight of the rats in the High Iron Group was lower than the Normal Iron Group. Meanwhile, the average amount food uptake of the High Iron Group had slightly decreased in the eighth week. In addition, the level of IL-6 in small intestine of the High Iron Group is higher than that of the Normal Iron Group (P

Keywords: Rat; Iron Overload; Growth and Development; Small Intestinal Mucosa (search for similar items in EconPapers)
Date: 2017
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DOI: 10.18483/ijSci.1212

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