Effects of 6-hydroxydopamine on the Expression of Iron Metabolism - Related Proteins in Primary Oligodendrocyte Progenitor Cells

Chen Zhi-qiang, Li Na and Wang Jun

International Journal of Sciences, 2017, vol. 6, issue 09, 82-84

Abstract: Oligodendrocyte progenitor cells play an important role in the formation of myelin sheath and the protection of neurons. After the action of 6- hydroxy dopamine on primary oligodendrocyte progenitor cells, elevated iron regulatory proteins resulted in an increase in Transferrin Receptor-1 and a decrease in Ferroportin-1 in oligodendrocyte progenitor cells.The extracellular iron entering cells is mediated by TfR1 endocytosis. As the expression of Transferrin Receptor-1 increases, the large number of extracellular iron moves into oligodendrocyte progenitors, but the expression of Ferroportin-1 was decreased, the intracellular iron turnover decreased, increase of iron content in the cell. 6-hydroxydopamine acts on oligodendrocyte progenitor cells leading to changes in intracellular iron metabolism, so that oligodendrocyte progenitor cells increased iron content.

Keywords: 6-hydroxydopamine; Primary Oligodendrocyte Precursor; IRP1; FPN1; TfR1 (search for similar items in EconPapers)
Date: 2017
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DOI: 10.18483/ijSci.1429

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