Prognostic Value of Hypoxia-Inducible Factor 1α in Solid Malignancies: A Meta-Analysis

Yuewen Qi, Shuai Zhang, Zhe Sun, Xiaolu Fang and Hong Yu

International Journal of Sciences, 2018, vol. 7, issue 03, 111-120

Abstract: Numerous studies have reported the prognostic role of Hypoxia-Inducible Factor 1α（HIF-1α）and solid malignancies, but the data of different reports remains controversial. To accurately evaluate the prognostic value of HIF-1α expression in solid malignancies, a meta-analysis based on published studies was conducted. Relevant studies from 34 observational articles with 3828 patients were collected via PubMed, Embase. These studies were chosen for the meta-analysis based on requisite criteria and the quality was evaluated using the Newcastle Ottawa Quality Assessment Scale. Hazard ratios (HRs) and 95% confidence interval (CIs) were pooled from studies on overall survival (OS) and disease-free survival (DFS) to estimate the association. The pooled HRs (95% CIs) of HIF-1α for OS and DFS were 1.94 [1.74, 2.16] and 2.16 [1.71, 2.74], respectively. The overall data of the shown meta-analysis suggested that the high expression of HIF-1α is correlated with poor survival outcome in solid malignancies.

Keywords: Hypoxia-Inducible Factor 1α; Prognostic; Solid Malignancies; Meta-Analysis (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1616

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