Effect of High Fructose Diet during Pregnancy on Progeny Metabolic Syndrome

Zi-yi Xiao, Lei Han, Juan He, Ting Zhao and Ruo-nan Wu

International Journal of Sciences, 2018, vol. 7, issue 03, 24-27

Abstract: Objective: To investigate the effect of high fructose diet during pregnancy on insulin resistance in the offspring. Methods: normal diet Wistar adult male rats and female rats were mated and pregnant rats were randomly divided into five groups: normal control group, normal dose group, high dose of fructose fructose group, high dose group and high dose of sucrose fructose group were given daily during pregnancy, 2mL of distilled water, 2g/kg 18g/kg, 6g/kg, 18g/kg and the fructose solution of sucrose solution by gavage, continuous intervention until delivery, delivery of rats fed with basic diet, and the rats weighing body weight, fasting blood glucose. The OGTT test was conducted at the end of the eighth week. After the next day of fasting 12h, the rats were killed, anesthesia, blood extraction, liver HE staining, serum insulin level, and insulin resistance index were measured. Results: during continuous intervention, birth weight childbirth offspring rats; OGTT test: at 30min, high dose group, high dose of fructose fructose group and high dose glucose sucrose group were significantly higher than normal control group and normal group (P

Keywords: Fructose; Fetal; IR; Blood Glucose (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1579

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