Association between Q115L of PINK1 Gene Polymorphism and Parkinson’s Disease: A Meta-Analysis

Zhicheng Liu and Zhiguo Liu

International Journal of Sciences, 2018, vol. 7, issue 03, 77-82

Abstract: Many case–control studies have researched the associations between PINK1 Q115L polymorphisms and the risk of Parkinson’s disease (PD), but the results exist controversies. We performed a meta-analysis to assess the possible association between the PINK1 Q115L gene polymorphisms and PD. Here we searched the Pubmed, CNKI, CBM and Web of Science databases up to 2015 to identify published related studies. The meta-analysis was then conducted to analysis the possible associations between the PINK1 Q115L polymorphisms and PD. A total of six studies were included in the meta-analysis. The crude odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated to evaluate the association. Heterogeneity among studies was evaluated using the I2 and Egger's test was used to evaluate publication bias. Sensitivity analysis was also performed. After exclusion of articles deviating from HWE in controls. The meta-analysis also showed no significant association between the T allele and increased risk of PD in allele model (FEM: OR=0.790, 95% CI=0.568-1.098); dominant model (FEM: OR=1.344, 95% CI=0.952-1.897); heterozygote model (FEM: OR=0.736, 95% CI=0.519-1.043). In subgroup analysis, for Caucasian, there was no significantly association in all three models. Our suggested that the PINK1 Q115L polymorphism might not be associated with PD.

Keywords: PINK1; Q115L; Parkinson’s Disease; Meta-Analysis; Mitochondria (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1585

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