Flavonoids from Herba epimedii Protect against MPP+-induced Toxicity in MES23.5 Cells

Na Li, Mingchun Jiang and Wenfang Chen

International Journal of Sciences, 2018, vol. 7, issue 04, 1-7

Abstract: Flavonoids, the active components of Herba epimedii (HEP), exerts many pharmacological effects, such as improvement of neurological function and sexual dysfunction, anti-osteoporosis and treatment of cardiovascular diseases in China over the centuries. According to the Chinese Pharmacopoeia, icariin, epimedin B and baohuoside-1 are three major flavonoid compounds isolated from HEP. The present study aims to characterize the neuroprotective effects of total flavonoid fraction of HEP and its three major flavonoid compounds against 1-methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity in MES23.5 cells. MTT assay showed that treatment with MPP+ significantly suppressed the cell viability. The effect could be respectively reversed by HEP, icariin, epimedin B and baohuoside-1 treatment in a dose-dependent manner. The present results provided the evidence that HEP and its main active compounds could protect against MPP+-induced neurotoxicity in dopaminergic MES23.5 cells.

Keywords: Herba epimedii; Icariin; Epimedin B; baohuoside-1; 1-methyl-4-phenylpyridinium ion; MES23.5 Cells (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1615

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