The Effect of Oxytocin on Food Intake in the Nucleus Accumbens Core

Ying Zhao, Wang Qian, Wang Cheng and Xu Luo

International Journal of Sciences, 2018, vol. 7, issue 04, 56-63

Abstract: Objective: In this experiment, we mainly investigated whether oxytocin (OT) acts on the Nucleus Accumbens Core (NAc) to regulate the feeding behavior of rats. Methods: Immunohistochemical experiment was used to observe the expression of OT receptor in NAc; To observe the effect of direct injection of OT in NAc on hunger- and palatability-driven food intake; c-Fos expression can be used as a marker of neuronal activation. After the NAc injection ofOT, the expression of c-fos in the hypothalamus was observed. Results: Studies found that the NAc injection of OT significantly reduced fasting-induced food intake and reduced intake of maltose and dextrin in non-fasted rats. Administration of the OTR antagonist L-368899 within NAc completely blocked these effects induced by OT. The results showed that intra-NAc injection of OT significantly activated NAc, as well as the other two brain regions associated with feeding: hypothalamic paraventricular nucleus and supraoptic nucleus. Conclusion: Injection of OT within NAc significantly attenuated starvation and reward-induced feeding behavior.

Keywords: Oxytocin; Arcuate nucleus; the Nucleus Accumbens Core; Food Intake (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1630

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