Study on the Effect of LHA on Feeding and its Mechanism

Wang Zhongxiang, Wang Mi, Wang Qian, Sun Xiangrong and Xu Luo

International Journal of Sciences, 2018, vol. 7, issue 04, 77-85

Abstract: Objective: To study the effect of lateral hypothalamic area on feeding and its specific mechanism. Methods: Intraventricular catheterization was used in rats,GLP-1 receptor agonist Ex4 or GLP-1 receptor antagonist Ex9 were injected into the lateral hypothalamic area (LHA) of rats, and the effects of food intake, water intake, body weight, kaolin intake and high-carbonhydrate diet were observed. Results: Immunohistochemical experiments showed the presence of GLP-1 receptor LHA in rats; When GLP-1 receptor was excited, the 1h and 24 h food intake of rats decreased, and the body weight decreased , and there was no significant change in the kaolin intake in rats; When GLP-1 receptor was blocked, there was no significant change in 24h food intake but weight gain in rats; When GLP-1 receptor was excited, high-carbonhydrate diet significantly reduced but there was no significant change in water intake; When GLP-1 receptor was blocked, high-carbonhydrate diet significantly increased but there was no significant change in water intake. Conclusion: GLP-1 receptor can be involved in the regulation of feeding behavior, and the signal may be related to the hedonicproperties of food.

Keywords: Food intake; GLP-1; LHA (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1627

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