Assessment of Large Granular Lymphocyte during Dasatinib Therapy and its Relation to Deep Molecular Response in Chronic Myeloid Leukemia

Haiqing Wang and Shupei Ma

International Journal of Sciences, 2018, vol. 7, issue 08, 33-36

Abstract: Objective: To compare the differences of deep molecular response (DMR) rate and time of obtaining DMR between dasatinib treated patients with increased and normal levels of large granular lymphocytes (LGLs) in newly diagnosed or imatinib resistant/intolerant chronic myeloid leukemia (CML) patients with positive BCR-ABL fusion gene. Methods: LGLs in peripheral blood were counted by flow cytometry and BCR-ABL fusion gene transcriptional level was detected by real-time quantitative polymerase chain reaction in 25 CML patients before and 1, 3, 6, 9, 12, 15, 18 months after dasatinib treatment. The enrolled patients were classified into LGLs+ group and LGLs- group according to whether the LGL counts were increased or not. Results: Among the 25 patients investigated, LGLs in 15 cases (5/15, 60%) were increased. Five cases in LGL+ group obtained DMR (33.3%) which was significantly higher than that of LGL- group (33.3% vs 10 %, P

Keywords: Chronic Myeloid Leukemia; Large Granular Lymphocyte; Dasatinib; Deep Molecular Response (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.ijsciences.com/pub/article/1763 (text/html)
https://www.ijsciences.com/pub/pdf/V72018081763.pdf (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adm:journl:v:7:y:2018:i:8:p:33-36

Ordering information: This journal article can be ordered from
https://www.ijsciences.com/payment_guide.php

DOI: 10.18483/ijSci.1763

Access Statistics for this article

More articles in International Journal of Sciences from Office ijSciences Alkhaer Publications Manchester M8 8XG England.
Bibliographic data for series maintained by Staff ijSciences ().