TG could Modulate FPN1 in MES 23.5 Cells by Hepcidin

Li Qi Jun

International Journal of Sciences, 2018, vol. 7, issue 09, 52-55

Abstract: Objective To observe the effects of thapsigargin (TG) on ferroportin1 (FPN1) in MES23.5 dopaminergic cell. Methods MES23.5 cells were treated with TG (0.1 μM or 1 μM) for 24h. the mRNA levels of hepcidin were measured using real-time PCR; The protein levels of CHOP, XBP-1s and FPN1 were measured using western blots. Results CHOP and XBP-1s expression was significantly higher in the TG-treated group than that in the control group; hepcidin mRNA levels in TG-treated group were up-regulated, this increase was to a larger extent in the 1 μM TG group when compare with the 0.1 μM TG group; however, FPN1 expression was significantly lower in the TG-treated group, this decrease was to a larger extent in the 1 μM TG group when compare with the 0.1 μM TG group. Conclusion TG could modulate FPN1 in MES23.5 cells by hepcidin.

Keywords: Parkinson’s Disease; MES23.5 Cells; ER Stress; Hepcidin; FPN1 (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1805

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