Changes of Learning and Memory Ability in fos-GFP Transgenic Mice

Chen W, Cao HaiS and Sun XiaoM
Authors registered in the RePEc Author Service: Wenyin Cheng

International Journal of Sciences, 2019, vol. 8, issue 02, 39-43

Abstract: Objective To study the changes of learning and memory ability in fos-GFP transgenic mice. Methods The mice in the fos-GFP group and the control were tested by using overhead cross maze,open field,and Morris Water Maze[1]. The spontaneous activity,anxiety state,the ability of learning and memory were tested as well. Results The differences between fos-GFP mice and the control were not significant in terms of distance of motion within the field,velocity,duration of stay at the marginal zone,and duration of open arm in the maze(p>0.05).The difference between the mice in the two groups was not significant with regard to latency of finding the flat at each time point(p>0.05),and the percentage of duration in target quadrant in Morris Water Maze(p>0.05),and similar freezing time in contextual fear conditioning test(p>0.05).The fos-GFP mice showed higher freezing level than normal controls in no-exposed fear conditioning(t=9.48,P

Keywords: fos-GFP Fused Protein; Learning; Memory; Neurobehavioral Manifestations; Mice (search for similar items in EconPapers)
Date: 2019
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DOI: 10.18483/ijSci.1981

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