Synthesis and Antibacterial Activity of Ursolic Acid Derivatives

Xiaoyuan Song, Junfang Li, Yimin Wang, Ganjun Yuan, Shan Lai, Houqin Yi and Pingyi Li

International Journal of Sciences, 2019, vol. 8, issue 09, 20-23

Abstract: To obtained natural products with remarkable antibacterial activities, three 3-amino substituted (UA) derivatives 2, 3 and 4 were designed and synthesized, and their antibacterial activity were assayed using broth microdilution method. Compared to UA, there three derivatives present higher antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) with the minimum inhibitory concentrations of 16 to 32 μg/mL. Furthermore, their cytotoxicities to human hepatoma cell (BEL-7402) were evaluated using MTT method, and the results indicated that their derivatives had no toxicity (IC50 value was larger than 10 μM), while UA presented a certain cytotoxicity.

Keywords: Ursolic Acid; Antibacterial Activity; Synthesis; Structural Modification; Mic; Mtt (search for similar items in EconPapers)
Date: 2019
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DOI: 10.18483/ijSci.2169

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