Role of Structural Dynamics in Leukocyte Integrins Function Interplay between the Shape-Shifting Mechanism and Allostery

Pragya Manandhar, Omar Abousaway, Trevor Le and Mehmet Sen
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Mehmet Sen: Department of Biology and Biochemistry, University of Houston, USA

International Journal of Cell Science & Molecular Biology, 2017, vol. 3, issue 4, 59-62

Abstract: This review concerns the recent progress on structural characterization of leukocyte integrins. Leukocyte integrins, also called CD18-integrins, are exclusively expressed on the leukocyte cell surface and modulate their trafficking in vasculature. Therefore, these integrins are major drug targets in autoimmune pathologies. Through initial drug development efforts, Efalizumab (Raptiva), designed to antagonize ligand-affinity of the LFA-1 integrin, was initially approved and originally marketed to treat psoriasis. However, the FDA and European Medicines Agency recommended suspension of Raptiva due to risk of progressive multifocal leukoencephalopathy (PML) as a result of immune suppression and concomitant activation of John Cunningham virus. In short, there is still an urgent need to design 2nd generation of anti-inflammatory drugs. Therefore, recent structural studies on leukocyte integrins, which have depicted unprecedented local and global motions, could be beneficial in the structure-guided drug design strategies.

Keywords: juniper publishers; Journal of Cell Science; Molecular Biology; International Journal of Cell Science; International Journal of Cell Science & Molecular Biology; molecular biology journals list; molecular biology impact factor; molecular biology scholarly journal; molecular biology online journals; molecular biology research papers; scientific journals; juniper publishers review (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:ijcsmb:v:3:y:2017:i:4:p:59-62

DOI: 10.19080/IJCSMB.2017.03.555617

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