MicroRNA: A Major Key in Pain Neurobiology

Unda, Santiago R, Villegas and Emilce A
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Emilce A: Instituto de Biotecnología, Centro de Investigación e Innovación Tecnológica, Universidad Nacional de La Rioja, Argentina

International Journal of Cell Science & Molecular Biology, 2017, vol. 3, issue 5, 73-79

Abstract: MiRNAs are single-stranded small noncoding RNAs that consist of approximately 22 nucleotides, that are involve in a wide range of biological processes including pain physiopathology. Because of their role as master switches in regulation and signaling pathways through modifications in nociceptive receptors, ion channels, pro-inflammatory molecules, emotional and cognitional behaviors associated with pain, the triggered enthusiasm for miRNAs as promising therapeutic targets is still active. Furthermore, the expression of specific miRNA can be helpful to predict treatment response in patients which suffer pain conditions that are poorly controlled by the currently available analgesics. This evidence is supported in several researches with animal pain models that we briefly review in this article to approximate in the understand of the role and neurobiology process through miRNA represents a major key for future therapeutics in pain, emphasizing in the neuropathic pain condition.

Keywords: juniper publishers; Journal of Cell Science; Molecular Biology; International Journal of Cell Science; International Journal of Cell Science & Molecular Biology; molecular biology journals list; molecular biology impact factor; molecular biology scholarly journal; molecular biology online journals; molecular biology research papers; scientific journals; juniper publishers review (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:ijcsmb:v:3:y:2017:i:5:p:73-79

DOI: 10.19080/IJCSMB.2017.03.555621

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