Refining the Role of Autophagy in Hypertrophic Cardiomyopathy

Shuyi Wang and Jun Ren
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Jun Ren: University of Wyoming College of Health Sciences, USA

International Journal of Cell Science & Molecular Biology, 2018, vol. 4, issue 3, 48-50

Abstract: Hypertrophic cardiomyopathy is perhaps the most prevalent form of inherited cardiomyopathy as a result of mutations in genes encoding components of the cardiac sarcomere. Although diagnosis of hypertrophic cardiomyopathy is relatively straightforward, its clinical management has been challenging due to lack of knowledge with regards to the precise pathogenesis of hypertrophic cardiomyopathy. A large body of evidence has recently suggested a pivotal role for impaired protein quality control machinery in inherited cardiomyopathies including hypertrophic cardiomyopathy. Here we will review recent findings on the role of autophagy in the etiology of hypertrophic cardiomyopathy and discuss therapeutic options available to restore autophagy-lysosomal function in an effort to benefit cardiac homeostasis in hypertrophic cardiomyopathy.

Keywords: juniper publishers; Journal of Cell Science; Molecular Biology; International Journal of Cell Science; International Journal of Cell Science & Molecular Biology; molecular biology journals list; molecular biology impact factor; molecular biology scholarly journal; molecular biology online journals; molecular biology research papers; scientific journals; juniper publishers review (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:ijcsmb:v:4:y:2018:i:3:p:48-50

DOI: 10.19080/IJCSMB.2018.03.555637

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