Evaluation of antioxidant and cytotoxic properties of Vernonia amygdalina

Omede A, Suleiman Ms, Atanu Fo, Momoh S, Friday Et, Sheneni Vd and Jegede Er
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Friday Et: Department of Biochemistry, Kogi State University, Nigeria
Jegede Er: Department of Medical Biochemistry, Kogi State University, Nigeria

International Journal of Cell Science & Molecular Biology, 2018, vol. 4, issue 4, 81-86

Abstract: The present investigation was carried out to evaluate the antioxidant activity and cytotoxic properties of Vernonia amygdalina. The free radical scavenging activity using a stable radical; 2, 2-Diphenyl-1-picryl hydrazyl, lipid peroxidation assay (DPPH), and nitric oxide inhibitory assay gave the highest percentage inhibition as 74.55±1.07%; IC50 = 1.831, 60.42±0.11; IC50 = 3.84 ± 1.03 and 71.26±0.48; IC50 = 0.99mg/ml, respectively. This is comparable to the standards quercetin used (P>0.05). In addition; total phenol, total flavoniods, anthocyanin and proanthocyanidine of the extract were determined using established methods. The results obtained justify the scavenging activity of the extracts. Furthermore, the extracts possessed very low cytotoxicity to brine-shrimp lethality test, when compared with the reference standard (Potassium dichromate, LC50 = 0.003±μg/mL).

Keywords: juniper publishers; Journal of Cell Science; Molecular Biology; International Journal of Cell Science; International Journal of Cell Science & Molecular Biology; molecular biology journals list; molecular biology impact factor; molecular biology scholarly journal; molecular biology online journals; molecular biology research papers; scientific journals; juniper publishers review (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:ijcsmb:v:4:y:2018:i:4:p:81-86

DOI: 10.19080/IJCSMB.2018.03.555644

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