Pre/Post Plasmid Curing and Killing Kinetic Reactivity of Discorea Bulbifera Linn Against Multiple Antibiotics Resistant Clinical Isolates, Using Escherichia Coli as A Case Study

Oludare Temitope Osuntokun, Agbi Mayowa, Thonda Oa and Aladejana Om
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Agbi Mayowa: Department of Microbiology, Adekunle Ajasin University, Nigeria
Aladejana Om: Department of Biological Science, Kings University, Nigeria

International Journal of Cell Science & Molecular Biology, 2019, vol. 6, issue 2, 46-56

Abstract: The emergence and spread of multidrug-resistant (MDR) bacteria to commonly used antibiotics is a severe health problem and a major challenge to global drug discovery. Plasmid-mediated multidrug resistance is one of the most imperative tribulations in the treatment of infectious diseases. The use of plasmid curing agents in association with antibiotics may serve as a feasible way to control the development and spread of antibiotic resistance encoded by antibiotic resistance plasmids (R-plasmids). This has encouraged scientists to constantly search for various plasmid curing agents and the introduction of this new approach to combat the problem of antibiotic resistance. Investigation on the antimicrobial properties of Discorea bulbifera was carried out against certain clinical isolates. The antimicrobial activities of ethanol extracts of this plant against some multiple resistant isolates was carried out using agar well diffusion method.

Keywords: juniper publishers; Journal of Cell Science; Molecular Biology; International Journal of Cell Science; International Journal of Cell Science & Molecular Biology; molecular biology journals list; molecular biology impact factor; molecular biology scholarly journal; molecular biology online journals; molecular biology research papers; scientific journals; juniper publishers review (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:ijcsmb:v:6:y:2019:i:2:p:46-56

DOI: 10.19080/IJCSMB.2019.06.555685

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