Genes and Genetics of Tuberculosis

Bhaswati Pandit
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Bhaswati Pandit: National Institute of Biomedical Genomics, India

International Journal of Pulmonary & Respiratory Sciences, 2017, vol. 1, issue 4, 99-104

Abstract: Tuberculosis affects human life globally for long time. About one third of the world’s population is infected with the causal pathogen Mycobacterium tuberculosis but without presenting any clinical symptoms. The difference in clinical outcome of infection suggests that host genetic makeup is responsible for such variability. Attempts have been made to identify the underlying genes. In case of Mendelian susceptibility to mycobacterial disease (MSMD) a rare disease with immune-deficiency, mutations were identified in genes that impair IFN γ signaling pathway. Linkage studies have identified several loci but exact gene was never pinpointed.

Keywords: uniper publishers:International Journal of Pulmonary; Journal of Pulmonary Sciences; Journal of Pulmonary & Respiratory Sciences; Pulmonary & Respiratory Sciences; pulmonary & respiratory medicine open access journals; pulmonary & respiratory medicine impact factor journals; pulmonary & respiratory medicine peer review journals; chronic obstructive pulmonary disease; pulmonary arterial hypertension impact factor journals; pulmonary aspergillosis high impact factor journals (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:ijoprs:v:1:y:2017:i:4:p:99-104

DOI: 10.19080/IJOPRS.2017.01.555567

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