Multiple Imputations for Determining an Optimum Biological Dose of a Metronomic Chemotherapy

Atanu B, Gajendra V, Jesna J and Ramesh V
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Atanu B: Centre for Cancer Epidemiology,The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC),Tata Memorial Centre, Mumbai, India
Gajendra V: Department of Applied Mathematics, Indian Institute of Technology -Dhanbad- 826004, India.
Jesna J: Department of Applied Mathematics, Indian Institute of Technology -Dhanbad- 826004, India.
Ramesh V: King Abdullah International Medical Research Center (KAIMRC),King Saud Bin Abdulaziz University for Health Sciences,Ministry of National Guard-Health Affairs,Riyadh,Kingdom of Saudi Arabia.

Biostatistics and Biometrics Open Access Journal, 2017, vol. 3, issue 5, 129-140

Abstract: The doses of chemotherapy selected in clinical practice are routinely obtained by the Maximum Tolerated Dose (MTD) approaches. It is believed that an increase in dose will lead to an increase in tumor response. The effect on angiogenesis is achieved by targeting Circulating Endothelial Cell(CEC). The effect on CEC is restricted to an antiangiogenic window in tumor cell line studies The challenge is to establish the optimal biological dose (OBD) of MC which would have maximized inhibiting effect on CEC.

Keywords: Biometrics Open Access Journal; Biostatistics and Biometrics; Biostatistics and Biometrics Open Access Journal; Open Access Journals; biometrics journal; biometrics articles; biometrics journal reference; biometrics journal impact factor; biometrics and biostatistics journal impact factor; journal of biometrics; open access juniper publishers; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jbboaj:v:3:y:2017:i:5:p:129-140

DOI: 10.19080/BBOAJ.2017.03.555621

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