Effects of Spironolactone About Vascular Inflammation on a Metabolic Syndrome Model

Nicolas F Renna, Rodrigo D Garcia, Jesica M Ramirez and Roberto M Miatello
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Nicolas F Renna: Department of Pathology, School of Medicine, National University of Cuyo, IMBECU-CONICET, Argentina
Rodrigo D Garcia: Department of Pathology, School of Medicine, National University of Cuyo, IMBECU-CONICET, Argentina
Jesica M Ramirez: Genetics Institute, School of Medicine, National University of Cuyo, Argentina
Roberto M Miatello: Department of Pathology, School of Medicine, National University of Cuyo, IMBECU-CONICET, Argentina

Current Research in Diabetes & Obesity Journal, 2019, vol. 11, issue 1, 18-27

Abstract: Background: Aldosterone (A) has pro-oxidative, pro-growth and pro-inflammatory effects in different tissues. We have previously demonstrated that in vascular inflammation different cytokines as NF-kB and VCAM-1 were present and generated a proinflammatory microenvironment that supports this cardiovascular remodeling. We proposed to evaluate the effects of spironolactone (S) antagonist mineralocorticoid receptor (MR) about vascular remodeling in metabolic syndrome model.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2019
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:11:y:2019:i:1:p:18-27

DOI: 10.19080/CRDOJ.2019.11.555804

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