GPR119 and GPR131: Functional Difference?

Yingxiao Li, Kai Chun Cheng and Juei-Tang Cheng
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Yingxiao Li: Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Kai Chun Cheng: Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Juei-Tang Cheng: Department of Medical Research, Chi-Mei Medical Center, Taiwan

Current Research in Diabetes & Obesity Journal, 2017, vol. 1, issue 3, 71-73 2Volume: 1

Abstract: Recently, two strategies are generally applied in clinical practice to treat diabetes, namely, glucagon like peptide-1 (GLP-1) analogs and inhibitors of the enzyme dipeptidylpeptidase-IV (DPP-4) that degrades both GLP-1 and glucose dependent insulin tropic polypeptide (GIP). Physiologically, after food ingestion, enteroendocrine cells in the intestinal mucosa may release the incretins, including GLP-1 and GIP, that can stimulate insulin secretion from endocrine pancreas and thereby decrease blood glucose. GLP-1 is produced and released mainly by L-cells located in the distal ileum while GIP is secreted by enteroendocrine K-cells in the proximal gut. However, GIP is not focused in clinics because diabetic patients are mostly GIP resistant. Therefore, development of agent(s) that may enhance GLP-1 pathway received increasing attentions in recent.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:1:y:2017:i:3:p:71-73

DOI: 10.19080/CRDOJ.2017.01.555566

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