Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimers Disease

Shashank Shekhar, Shaoxun Wang, Paige N Mims, Ezekiel Gonzalez-Fernandez, Chao Zhang, Xiaochen He, Catherine Y Liu, Wenshan Lv, Yangang Wang, Juebin Huang and Fan Fan
Additional contact information
Shashank Shekhar: Department of Neurology, University of Mississippi Medical Center, USA
Shaoxun Wang: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Paige N Mims: 3Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Ezekiel Gonzalez-Fernandez: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Chao Zhang: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Xiaochen He: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Catherine Y Liu: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Wenshan Lv: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
Yangang Wang: Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, China
Juebin Huang: Department of Neurology, University of Mississippi Medical Center, USA
Fan Fan: Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, China

Current Research in Diabetes & Obesity Journal, 2017, vol. 2, issue 3, 40-45

Abstract: Alzheimer’s disease (AD) is the leading cause of progressive degenerative dementia. The hallmark pathological features include beta amyloid deposition and neurofibrillary tangles. There has been astrong association of AD with Diabetes (DM) based on human studies and animal experiments. The hallmark features of AD seem to have an exaggerated presence in AD with DM, especially type 2 diabetes (T2D). In addition, insulin resistance is a common feature in both diseases and as such AD has been called type 3 diabetes. Furthermore, impairment of cerebral autoregulation has been reported in both animal and human diabetic subjects. Cerebral vascular impairment has also been implicated in the pathophysiology of AD. There is an urgent need to develop animal models of AD and DM to explore the neuropathological mechanisms of these disease and utilize such models to develop treatment strategies

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:2:y:2017:i:3:p:40-45

DOI: 10.19080/CRDOJ.2017.02.555587

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