TGR5 as New Target in Diabetes Care

Juei-Tang Cheng, Chih-Chan Lin and Hsiao Yin Lien
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Juei-Tang Cheng: Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan 71003
Chih-Chan Lin: Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan 71003
Hsiao Yin Lien: Department of Pharmacy, Veterans General Hospital, Kaohsiung City, Taiwan 81362

Current Research in Diabetes & Obesity Journal, 2018, vol. 9, issue 2, 52-54

Abstract: The bile acid binding receptor TGR5 is suitable as a new target for the handling in metabolic disorders, including type 2 diabetes, obesity, and fatty liver. TGR5 is known to express in various tissues, but the enterohepatic cycling limits bile acid to activate the receptors. The preclinical data demonstrated the merits of TGR5 activation in cases such as weight loss, glucose regulation, energy metabolism, and the lowering of inflammation. Studies in animals indicated the important role of Tgr5 in GLP-1 secretion, insulin sensitivity, and energy metabolism. However, evidence regarding these effects in clinical practice is still not enough. Therefore, we call the development of safe and selective TGR5 agonist(s) using the distinguished subtype of TGR5 in the near future.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:9:y:2018:i:2:p:52-54

DOI: 10.19080/CRDOJ.2018.09.555760

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