Prospects to Enhance Phage Therapy by Looking At CRISP Fingerprints in Bacterial Populations

Vladimir Zlobin I, Yuri Dzhioev P, Nadezhda Peretolchina P, Andrey Borisenko Y, Liliya Stepanenko A, Yingchen Wang, Zhangyi Qu, Rian Pierneef, Oleg Reva N and Rian Pierneef
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Liliya Stepanenko A: Scientific and Research Institute of Biomedical Technologies of the Irkutsk State Medical University, Russia
Rian Pierneef: Department Microbiology, Harbin Medical University, 157, China
Rian Pierneef: Department of Biochemistry, University of Pretoria, South Africa

Current Trends in Biomedical Engineering & Biosciences, 2018, vol. 10, issue 5, 99-101

Abstract: In the last decade CRISPR/Cas systems have been used extensively in different areas of research from bacterial genotyping to genetic engineering. CRISPR/Cas systems are accurate and precise molecular devices designed by the nature, with the primary role being bacterial defence against foreign genetic elements, mainly bacteriophages. The recent advances in sequencing technologies have created opportunities for application of CRISPR/Cas systems in personalized phage therapy and in fundamental studies of co-functioning of bacterial and phage populations in the nature. However, as always, new opportunities mean new technical challenges and demands for innovative bioinformatics tools. This review introduces an initiative of the BRICS consortium, consisting of three research centres in Russia, China and South Africa, to develop a comprehensive interactive resource to source data and software tools for personalised phage therapy.

Keywords: juniper publishers group; juniper publishers Biomedical Engineering journals; Biomedical Engineering journals list; medical devices journals; peer reviewed Biomedical Engineering journals; open access Biomedical Engineering journals; Biomedical Engineering journals impact factor; Biomedical Engineering scientific journals; Biomedical Engineering articles; scholarly Biomedical Engineering journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:10:y:2018:i:5:p:99-101

DOI: 10.19080/CTBEB.2018.10.555800

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