Development of Advanced-Laser Micro Dissection System for Protein Aggregation Diseases

Naomi Hachiya and Yoshimichi Kozuka
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Naomi Hachiya: Research and Development Department, Biotechnology Group, Tokyo Metropolitan Industrial Technology Research Institute, Japan
Yoshimichi Kozuka: Shinku-Device Instrument, Japan

Current Trends in Biomedical Engineering & Biosciences, 2018, vol. 12, issue 4, 75-78

Abstract: Results of the remarkable increase of life expectancy, the number of patients that have age-related diseases are increasing. Protein aggregation diseases are belonging to such diseases, and that submicron order of highly aggregated inclusions formed in tissues. Nowadays, effective therapeutic approaches are required, however, etiology of the diseases remain to be elucidated. One reason is that the size of inclusion is too small to purify without contamination especially in some disease cases thus we have difficulty in analyzing them biochemically. Therefore, it wouldn’t be surprise that we hardly get reliable results even when we use a highly sensitive mass spectrometry in research. To solve this problem, we have developed an improved laser microdissection system; (Advanced-LMD) consisted of a deep ultraviolet laser with 266 nm of wavelength and fluorescent microscopy. Advanced-LMD can isolate minute size of inclusions derived from tissues.

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Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:12:y:2018:i:4:p:75-78

DOI: 10.19080/CTBEB.2018.12.555841

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