MAPK and AKT Pathway Intersection in Neuroblastoma Cells

Aysegul Yildiz and Ozgur Tanriverdi
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Aysegul Yildiz: Department of Molecular Biology and Genetics, Muğla Sıtkı Koçman University, Turkey
Ozgur Tanriverdi: Molecular Biology and Genetics, Muğla Sıtkı Koçman University, Turkey

Current Trends in Biomedical Engineering & Biosciences, 2017, vol. 2, issue 1, 17-20

Abstract: One of the most important contributing factors for cancer development is the aberrant activation of mitogenic MAPK and AKT survival pathways. Abnormal activities of these pathways also indicates poor prognosis as a result of drug resistance in cancer treatment. It is revealed that there is a cross-talk between these two signaling cascades and they act together by one triggering the other performing an anti-apoptotic effect. It is evident that interplay between MAPK and AKT pathways is at the center of poor prognosis especially in neuroblastoma. However, it is still unknown what is there at the heart of this interaction. In this mini review, tumorigenic and chemotherapy-resistant effects of MAPK and AKT pathways and also the effect of their cross-talk in neuroblastoma and other cancers is summarized.

Keywords: juniper publishers group; juniper publishers Biomedical Engineering journals; Biomedical Engineering journals list; medical devices journals; peer reviewed Biomedical Engineering journals; open access Biomedical Engineering journals; Biomedical Engineering journals impact factor; Biomedical Engineering scientific journals; Biomedical Engineering articles; scholarly Biomedical Engineering journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:2:y:2017:i:1:p:17-20

DOI: 10.19080/CTBEB.2017.02.555580

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