In Vitro Anti-Inflammatory Activity of L-Asparaginase from Soil Rhizosphere Fungus Aspergillus tamarii

Mahabal Ns and Kaliwal Bb
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Mahabal Ns: Department of Biotechnology and Microbiology, Karnatak University, India
Kaliwal Bb: Department of Microbiology, Davangere University, India

Current Trends in Biomedical Engineering & Biosciences, 2017, vol. 4, issue 5, 80-84

Abstract: In recent years L-asparaginase has been gaining interest of researchers as it is a potential anti-tumor drug. It has also been reported that the enzyme also possesses anti-inflammatory property. That present investigation is an insight to the in vitro anti-inflammatory property of L-asparaginase extracted from fungus Aspergillus tamarii. The in vitro assessment methods included albumin denaturation assay, proteinase inhibitory activity and membrane stabilization using Diclofenac sodium and Aspirin as standard drugs. In the present study L-asparaginase (10μg/ml to 50μg/ml) was used as the test sample for anti-inflammatory tests. The results indicated that 50 μg/ml of L-asparaginase showed significant inhibition values. 52.38% of albumin denaturation, 46.87% of proteinase inhibition, 55.26% of haemolysis inhibition and 51.21% of inhibition of hypotonic induced haemolysis. The results indicate that L-asparaginase extracted from Aspergillus tamarii possesses anti-inflammatory property apart from being an anti-tumor drug.

Keywords: juniper publishers group; juniper publishers Biomedical Engineering journals; Biomedical Engineering journals list; medical devices journals; peer reviewed Biomedical Engineering journals; open access Biomedical Engineering journals; Biomedical Engineering journals impact factor; Biomedical Engineering scientific journals; Biomedical Engineering articles; scholarly Biomedical Engineering journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:4:y:2017:i:5:p:80-84

DOI: 10.19080/CTBEB.2017.04.555647

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