Decellularized Human Liver Tissue Fragments to Create Cell - and Tissue-Engineered Liver Constructs

Nemets Ea, Kirsanova La, Basok Ju B, Lymareva Mv, Schagidulin M Ju and Sevastianov
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Sevastianov: Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation, Russia

Current Trends in Biomedical Engineering & Biosciences, 2017, vol. 8, issue 5, 112-115

Abstract: One of the problems of creating a bioengineered liver as an alternative to the donor liver transplantation for the treatment of end-stage liver failure, is finding the matrix, capable of performing temporarily the functions of a natural extracellular matrix (ECM) and providing the necessary conditions to maintain the viability and functionality of liver cells. The main disadvantage of resorbable biopolymer matrices is the absence of tissue-specific properties and the impossibility of reproducing the unique structure of the liver ECM. The aim of this work was the development of technology for decellularization of liver tissue fragments while preserving the structural properties of the native liver ECM.

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Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:8:y:2017:i:5:p:112-115

DOI: 10.19080/CTBEB.2017.08.555747

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