Radiotoxicity to Tumor Cells Enhanced By Triphala- Cellular and Animal Studies

Mishra Kp and Das St
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Das St: Foundation for Education and Research, India

Cancer Therapy & Oncology International Journal, 2018, vol. 11, issue 1, 8-15

Abstract: Research results from our laboratory have shown that Triphala (TPL) induced cytotoxicity in cancer cells in vitro as well as in vivo involving the mechanism of reactive oxygen species (ROS) induced apoptosis. We have pursued this study to examine the ability of TPL to enhance radiation induced cytotoxicity in MCF-7 cells in vitro and transplantable thymic lymphoma, barcl-95 and fibrosarcoma in mice in vivo. It was found that MCF-7 cells subjected to ï §-radiation (3 Gy) prior to treatment with TPL showed a significant increase in loss of viability compared with the drug treatment alone. The increased radiotoxicity of tumor cells by Triphala was found to be concentration dependant. It was further found that combined treatment of cells with ï §-radiation (3 Gy) and TPL (0.5mg/ml) induced a higher percentage of apoptosis, in MCF-7 cells than either with radiation or TPL alone. MCF-7 cells treated with TPL and ï §-radiation showed a substantial increase in intracellular reactive oxygen species (ROS) and decrease in mitochondrial membrane potential. Experiments on TPL effect on tumour growth showed that TPL fed to mice (1mg/mice/day for 14 days) for 7 days prior and 7 days after irradiation transplanted with barcl resulted in the reduction of tumor volume by 47% as compared to that of radiation treated (27%) and TPL treated (33%). The data showed that TPL exerted radiosensitizing effect on tumor cells in vitro as well as in vivo which may be applicable in improving cancer radio therapy.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:11:y:2018:i:1:p:8-15

DOI: 10.19080/CTOIJ.2018.11.555802

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