Some Trace Element Contents and Ratios in Prostatic Fluid as Ancillary Diagnostic Tools in Distinguishing Between the Benign Prostatic Hyperplasia and Prostate Cancer

Vladimir Zaichick and Sofia Zaichick
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Vladimir Zaichick: Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia
Sofia Zaichick: Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, USA

Cancer Therapy & Oncology International Journal, 2019, vol. 14, issue 1, 9-15

Abstract: Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) is an internationally important health problem of the man. The association between PCa and BPH is significant. As a result of this, BPH may be misdiagnosed as a malignant condition. This warrants the need of reliable diagnostic tool which has ability to differentiate BPH from the PCa. The aim of this exploratory study was to evaluate whether significant difference in the contents of Zn and some other trace elements as well as in the Zn/trace elements ratios of prostatic fluid exist between the hyperplastic and malignantly transformed prostate. Prostatic fluid levels of Br, Fe, Rb, Sr, and Zn were prospectively evaluated and Zn/Br, Zn/Fe, Zn/Rb, and Zn/Sr ratios were calculated in 52 patients with BPH and 24 patients with PCa. Measurements were performed using energy dispersive X-ray fluorescent microanalysis. It was found that in the prostatic fluid samples of PCa group the levels of Rb, Zn, Zn/Br, Zn/Fe, and Zn/Sr are 3.2, 7.7, 23.8, 30.3, and 16.1 times, respectively, lower than levels of these parameters of patients with BPH. It was supposed that the changes of Rb, Zn, Zn/Br, Zn/Fe, and Zn/Sr levels in the prostatic fluid samples can be used as tumor markers in distinguishing between BPH and PCa.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:14:y:2019:i:1:p:9-15

DOI: 10.19080/CTOIJ.2019.14.555879

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