Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines

Qurat-ul-Ain
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Qurat-ul-Ain: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Cancer Therapy & Oncology International Journal, 2020, vol. 16, issue 3, 52-60

Abstract: A library of substituted pyrimidines was synthesized and evaluated for free radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds showed good free radical scavenging activity with IC50 values in the range of 42.9 ± 0.31 to 438.3 ± 3.3 μM as compared to the standard butylated hydroxytoluene having IC50 value of 128.83 ± 2. 1 μM. The structure activity-relationship was also established. Selected analogues 1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 13, 15, 19, 20, 21, 24, 25, 26 and 28 were tested for cytotoxicity in mouse fibroblast 3T3 cell line using MTT assay, and most of the analogues showed cytotoxicity. This study has identified a number of cytotoxic novel substituted pyrimidines having free radical scavenging activities that can be used as inhibitory compounds for those cancer cells whose growth is mediated by reactive oxygen species.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:16:y:2020:i:3:p:52-60

DOI: 10.19080/CTOIJ.2020.16.555940

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