Extraneural Glioblastoma Metastasis: A Case Report

Selcuk Demiral, Omer Sager, Ferrat Dincoglan, Bora Uysal, Hakan Gamsiz, Yelda Elcim, Bahar Dirican and Murat Beyzadeoglu
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Murat Beyzadeoglu: Department of Radiation Oncology, University of Health Sciences, Turkey

Cancer Therapy & Oncology International Journal, 2017, vol. 7, issue 3, 46-48

Abstract: Glioblastomas comprise the most common and the most malignant of primary brain tumors with a dismal prognosis. While local failure is very common even after definitive multimodality management, extracranial distant metastasis is extremely infrequent due to the absence of lymphatic drainage. In this case report, we present a 44-year-old male patient presenting with an intracranial lesion who was diagnosed to have World Health Organization (WHO) grade II oligodendroglioma following subtotal excision. Conventionally fractionated radiotherapy at a dose of 54 Gy was delivered to the local cranium after surgery. After 3 years of follow-up without progression, he was diagnosed with recurrent disease and the histopathological assessment revealed a WHO grade IV glioblastoma with malignant transformation. He had bone metastasis together with an involved neck node by direct extension. Symptomatic relief was achieved after salvage chemoirradiation. The patient is still alive after 4 years from the first diagnosis. Extracranial neck node metastasis together with bone metastasis of glioblastoma may be seen though very rarely reported in the literature. Substantial improvement in symptoms may be achieved with multimodality management in the setting of the very rare occurrence of extraneural glioblastoma metastasis.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:7:y:2017:i:3:p:46-48

DOI: 10.19080/CTOIJ.2017.07.555715

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