Cellular Modeling of Cancer Therapy Induced Cardiotoxicity

William P Bozza, Keisha Melodi McSweeney and Baolin Zhang
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Baolin Zhang: Center for Drug Evaluation and Research, Food and Drug Administration, USA

Cancer Therapy & Oncology International Journal, 2018, vol. 9, issue 1, 1-4

Abstract: Drug-induced cardiotoxicity is a major safety concern in cancer therapy. Cytotoxic agents and targeted therapies used to treat cancer, including classic chemotherapeutic agents, monoclonal antibodies that target tyrosine kinase receptors, small molecule tyrosine kinase inhibitors, and even antiangiogenic drugs, all affect the cardiovascular system. Examples of clinical cardiotoxic side effects include reduction of left ventricular ejection fraction, arrhythmia, cardiomyopathy, myocarditis, heart failure, and even cardiac death [1,2]. The current clinical surveillance and monitoring approaches for cardiac dysfunction during cancer

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:9:y:2018:i:1:p:1-4

DOI: 10.19080/CTOIJ.2018.09.555751

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