The Hedgehog Signaling Pathway: A Promising Target for Therapeutic Development

Nahla AM Hamed
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Nahla AM Hamed: Faculty of Medicine, Alexandria University, Egypt

Cancer Therapy & Oncology International Journal, 2018, vol. 9, issue 4, 130-132

Abstract: The Hh pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation. The Hh signaling pathway is activated in many cancers. It has been suggested that Hh promote cancer by directly regulating cellular growth and/ or survival. Hh signaling also desensitizes tumor cells to radiotherapy and to therapies. Preliminary evidence implicates Hh signaling in diminished immune functions against tumors. Understanding the specific mechanism of Hh activation in a particular tumor might help in optimizing the most appropriate agent and strategy obtained by Hh pathway inhibition.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:9:y:2018:i:4:p:130-132

DOI: 10.19080/CTOIJ.2018.09.555773

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