Could We Hack Women’s Biological Clock? A Mitochondrial Hypothesis

Ana T Marcos and Jose M Navarro-Pando
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Jose M Navarro-Pando: Department of Genetics, Instituto para el Estudio de la Biología de la Reproducción Humana INEBIR, Seville, Spain

Global Journal of Reproductive Medicine, 2018, vol. 3, issue 2, 33-35

Abstract: Our knowledge about aging infertility suggests that oocyte quality is the major contributing factor. Assisted reproductive technologies (ART) teach us two critical facts about this topic: the reduction of reproductive capacity observed in aged women is related with the oocyte´s age, and how we can reverse the aging process getting high rates of live-birth pregnancies achieved by aged women with oocytes donated by younger women. The biologic reason why older women have a lower pregnancy rate is because aneuploid embryos are more frequently obtained from aged women. In this context, the quality of oocyte mitochondria is determinant in embryo quality, relating to euploid embryos, since mitotic non-disjunction occurs more frequently in advanced aged women [1].

Keywords: Journal of Reproductive Medicine; Reproductive Medicine; journal of reproductive medicine; reproductive medicine articles; reproductive medicine articles impact factor; reproductive medicine research journals; reproductive journals list; open access; juniper publishers journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjorm:v:3:y:2018:i:2:p:33-35

DOI: 10.19080/GJORM.2018.03.555608

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