Formulation and Evaluation of Solid Dispersion of Glimepiride in to Sustained Release

Anusha Pagadala, Madhuri Asiniparthi and Vaidehi Donti
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Vaidehi Donti: Pharmaceutics Department, Gyana Jyothi College of Pharmacy, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2016, vol. 1, issue 2, 18-22

Abstract: A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:1:y:2016:i:2:p:18-22

DOI: 10.19080/GJPPS.2016.01.555553

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