Deuteration as a Tool for Optimization of Metabolic Stability and Toxicity of Drugs

Sukhninder Kaur and Monika Gupta
Additional contact information
Monika Gupta: ASBASJAM College of Pharmacy, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 1, issue 4, 79-90

Abstract: Deuteration is an effective tool for the enhancement of drug’s metabolic profile. Selective replacement of hydrogen with deuterium leads to increased bond strength which in turn increases the biological half-life and thus metabolic stability of the drug. Apart, deuterium substitution may also results in metabolic shunting leading to reduced exposure of vital organs to undesirable/toxic metabolites or increased exposure to desired active metabolites. This review emphasizes on various examples where deuteration came up with enhancement of metabolic stability of drug and reduction in toxicity relative to the untreated drug while retaining its significant pharmacological profile.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/gjpps/pdf/GJPPS.MS.ID.555566.pdf (application/pdf)
https://juniperpublishers.com/gjpps/GJPPS.MS.ID.555566.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:1:y:2017:i:4:p:79-90

DOI: 10.19080/GJPPS.2017.01.555566

Access Statistics for this article

Global Journal of Pharmacy & Pharmaceutical Sciences is currently edited by Sophia Mathis

More articles in Global Journal of Pharmacy & Pharmaceutical Sciences from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().