Extractive Spectrophotometric Methods for the Determination of Dothiepin in Pure and Pharmaceutical Formulations

Umamaheswar K, Naganjaneyulu T and Rambabu C
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Rambabu C: Department of Chemistry, Acharya Nagarjuna University, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 2, issue 2, 25-29

Abstract: Two sensitive and accurate extractive spectrophometric methods have been developed for the estimation of dothiepin in pure and pharmaceutical dosage forms. The developed methods are based on the formation of colored solvent extractible ion-association complexes of the drug with bromocresol blue [BCB] and eriochrome black-T [EBT]. The extracted complexes showed absorbance maxima at 418 and 508 nm respectively. Beer’s law is obeyed in the concentration ranges between 16 - 56 and 5-17.5μg/mL for the two methods respectively. The effective concentration of dye, pH and optimum conditions are established for these methods. The methods are applied for the determination of the drug in commercial tablets and results of analysis are validated statistically through recovery studies.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:2:y:2017:i:2:p:25-29

DOI: 10.19080/GJPPS.2017.02.555582

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