Is There a Role Of Resveratrol in Doxorubicin- Induced Hepatotoxicity?

Dorsaf Ben Gaied and Arnaud P
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Arnaud P: Unité de Technologies Chimiques et Biologiques pour la Santé, Faculty of pharmacy of Paris, France

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 3, issue 1, 12-14

Abstract: Doxorubicin (DOX) has been used in the treatment of variety of cancers but its administration is limited by a dose-dependent toxicity. Its cytotoxic effects on malignant cells, have shown an increase in the risk of cardiotoxicity, hepatoxicity, renal failure. Antioxydants have been explored for both their cancer preventive properties and chemodulatory of DOX toxicity. Resveratrol (RSV) is a polyphenolic constituent of several dietary mainly of grapes and wine origin recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in-vitro and in-vivo. RSV is also known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, RSV have a great medicinal value, its applications as a therapeutics are limited.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:3:y:2017:i:1:p:12-14

DOI: 10.19080/GJPPS.2017.03.555603

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