Simultaneous UV Spectrophotometric Estimation of Acebutalol Hydrochloride and Hydrochlorothiazide in Bulk and Combined Tablet Dosage Form

Pawar Seemarani, Jadhav S, Tamboli A, Shaikh A and Mali S
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Mali S: Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 3, issue 1, 15-18

Abstract: There is not a single analytical methods appeared in the literature for combined estimation of Acebutalol Hydrochloride and Hydrochlorothiazide in tablets dosage form. Attempts were made to develop a simple, precise and accurate Simultaneous UV spectroscopic method of Acebutalol Hydrochloride and Hydrochlorothiazide in bulk and Sectrazide tablet dosage form by using simultaneous equation method. UV spectrophotometric method was developed and validated as per ICH guidelines using methanol as mobile phase. Acebutalol Hydrochloride and Hydrochlorothiazide individually follows the Beer-Lamberts law over concentration range 3-18μg/ml and 1-6μg/ml, regression of coefficient was found to be r2=0.9999 and r2=0.9999 respectively. The percentage recovery was found in the range of 98% to 102% at three different levels. The proposed method was successfully applied for the determination of Acebutalol Hydrochloride and Hydrochlorothiazide in tablets dosage form as per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:3:y:2017:i:1:p:15-18

DOI: 10.19080/GJPPS.2017.03.555604

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