Comparative In-Vitro Equivalence Evaluation of Fexofenadine Hydrochloride 120mg Generic Tablets Marketed in Bangladesh

Sabreena Chowdhury Raka, Bodiuzzaman Bsm and Arifur Rahman
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Bodiuzzaman Bsm: Department of Pharmacy, Daffodil International University, Bangladesh
Arifur Rahman: Department of Pharmacy, BRAC University, Bangladesh

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 3, issue 1, 6-11

Abstract: Fexofenadine hydrochloride, a piperidine derivative, is indicated to relieve signs and symptoms related with seasonal allergic rhinitis, such as rhinorrhoea, sneezing nose, throat and itchy eyes. The aim of my study is to establish the pharmaceutical equivalence of different brands of fexofenadine hydrochloride 120mg film coated tablets available in Bangladesh. The quality control parameters which are studied are weight variation test, thickness, friability, hardness, disintegration, dissolution and assay specified by British and United State Pharmacopoeia. The assay value was determined by HPLC. Out of the tablets from six evaluated pharmaceutical companies, the potency of fexofenadine hydrochloride tablets from four companies was found to be satisfactory and two was poor of the range.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:3:y:2017:i:1:p:6-11

DOI: 10.19080/GJPPS.2017.03.555602

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