Studies on In-Vitro Antiglycation Potential of Some Indigenous Antidiabetic Plants

Mangesh Bhutkar, Somnath Bhinge, Dheeraj Randive, Ganesh Wadkar and Sachin Todkar
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Sachin Todkar: Rajarambapu College of Pharmacy, Indiaa

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 3, issue 5, 127-130

Abstract: The in vitro antiglycation activity of extracts of some traditional antidiabetic plants was studied by determining the degree of non-enzymatic hemoglobin glycosylation. The best concentration and time required to incubate glucose with hemoglobin was estimated. Thereafter, the glycosylation degree of hemoglobin in the presence of plant extracts under study at different concentrations and in their absence was measured calorimetrically. The inhibitory affect on glycosylation of hemoglobin at the four concentrations namely 250μg/ml, 500μg/ml, 750μg/ml and 1000μg/ml were determined as follows: for A. lebbeck 19.08%, 29.22%, 37.86% and 48.55%, B. aristata; 29.66%, 37.05%, 49.0%, 56.17%, M. pruriens; 45.83%, 58.73%, 70.14%, and 75.60% respectively. The studies demonstrated that non-enzymatic nature of hemoglobin glycosylation could be effectively inhibited by the extracts of M. pruriens, B. aristata and A. lebbeck at a desirable concentration.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:3:y:2017:i:5:p:127-130

DOI: 10.19080/GJPPS.2017.03.555624

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