Experimental Design Approach for Optimization of Sucrose Fluid Bed Drying Process Conditions

Amira Touil and Ahlem Haj Ammar
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Ahlem Haj Ammar: High Institute of Environment Science and Technology, Technopole Borj Cedria, Tunisia

Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, vol. 4, issue 1, 5-11

Abstract: The present study investigated the effect of operating parameters of sucrose fluid bed drying on powder quality and on drying time, in order to optimize the production of sucrose powders. A 24-1 fractional factorial design of experiment has been used. After an appropriate choice of four critical variables. 8 experiments led to a mathematical model as a first degree polynomial presenting the response functions (color and drying time) in relation to the operating parameters. From the retained model, we were able to calculate the average response, the different effects and their interactions. The results showed that gas flow and sugar particle size had significant effects (in absolute values) on the quality of the sugar dried, at a 95% confidence interval. Sucrose presented the best quality and the lower time treatment at the lower gas flow rate and at larger particle size. Analyzing the variance (ANOVA) showed that the model is highly significant and can adequately describe the experimental range.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:4:y:2017:i:1:p:5-11

DOI: 10.19080/GJPPS.2017.04.555628

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