Effects of Ethanol Extract Leaves of nymphaea lotus (water lily) on Learning and Memory in CD-1 Mice

Nomso C and Aduema W
Additional contact information
Aduema W: Department of Human Physiology, Gregory University, Nigeria

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 4, issue 3, 55-62

Abstract: Nymphea lotusis a perennial and herbaceous aquatic plant, whose leaves floats or submerged in water across the regions of Africa. The plant has be reportedly used for various therapeutic purposes (such as aphrodisiac, antioxidant and antibacterial purposes) including the treatment of fever, diarrhea, urinary difficulties, enteritis, dyspepsia, bowel problems tumours, gastric ulcers and abnormal heart beat. The present study investigates the effect of the ethanolic extract of Nympheae lotus on learning and memory in mice. The Morris water maze test was used to evaluate the neuro-cognitive effects of this plant. Before the neurobehavioral parameters were assessed, the LD50, Photochemical and acute toxicological screenings of the plant were determined. The median lethal dose was above 5000mg/kg orally in mice for the ethanol extract. Twenty seven (27) Swiss mice were randomly assigned into 3 groups; control (normal saline), low dose (200mg/kg) and high dose (400mg/kg) for fourteen days (14).

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/gjpps/pdf/GJPPS.MS.ID.555638.pdf (application/pdf)
https://juniperpublishers.com/gjpps/GJPPS.MS.ID.555638.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:4:y:2018:i:3:p:55-62

DOI: 10.19080/GJPPS.2018.04.555638

Access Statistics for this article

Global Journal of Pharmacy & Pharmaceutical Sciences is currently edited by Sophia Mathis

More articles in Global Journal of Pharmacy & Pharmaceutical Sciences from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().