Celastrol Mediated Hsp90 Protein Inhibition in Cancer

Dharambir Kashyap and Hardeep Singh Tuli
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Hardeep Singh Tuli: Department of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 5, issue 1, 5-7

Abstract: In 2012, according to the globocan data 14.2 million new cases of cancer and 8.2 million cancer associated deaths had been reported. Lack of knowledge in cancer biology has major role for such disaster which increasing the enthusiasm to come up with promising anti-cancer therapy [1]. Discovery of new drug targets in cancer cell urgently required to reduce the mortality and to increase survival rate. The aberrant expression of Heat shock protein (Hsp) 90 has been correlated in all the cancer processes such as cell cycle arrest, angiogenesis, and metastasis [2-8]. So, identification of Hsp90 function in tumor cell may really be helpful which could serve as prognosis biomarker. The Hsp90 is a major molecular chaperone abundantly expressed in all cell types and plays pivotal role in correct folding and functionality of client proteins [9,10].

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:5:y:2018:i:1:p:5-7

DOI: 10.19080/GJPPS.2018.05.555652

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