Peg-5 Oleate Based Self Microemulsifying Drug Delivery System: As a Versatile Approach in Oral Bioavailability Enhancement of Anti-Diabetic Agent: Formulation Design, vitro/In vivo Evaluation & Stability Studies

Vikas Pandey and Seema Kohli
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Vikas Pandey: Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, India
Seema Kohli: Departmen of Pharmaceutical Sciences, Kalaniketan Polytechnic College, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 5, issue 5, 103-113

Abstract: The rationale of this research work was to develop and characterize self-micro emulsifying drug delivery system (SMEDDS) of repaglinide (RPG). The solubility of RPG was analyzed in various excipients. Pseudo ternary phase diagram was used to evaluate the micro-emulsification existence area. SMEDDS formulation (ME1, ME2, ME3, ME4&ME5) were examined for micro-emulsifying properties, and the consequential formulations loaded with RPG were investigated for clarity, phase separation, globule size and shape, zeta potential, thermodynamic and thermal stability. Out of five formulations developed three (ME1 , ME2&ME3) were found to be suitable from the point of view of above mentioned parametrical studies and were consecutively subjected to stability studies as per International conference on Harmonization (ICH) guidelines. Accelerated and long term conditions of a period of 3 months indicated no such noteworthy changes. TEM micrographs of microemulsion formulations further assured the spherical shape of globules. Developed SMEDDS formulation showed superior performance in in-vitro drug release and in-vivo studies in contrast to marketed RPG formulation (tablets) and pure RPG drug.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:5:y:2018:i:5:p:103-113

DOI: 10.19080/GJPPS.2018.05.555671

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