Development and Validation of A RP- HPLC Method for the Simultaneous Estimation of Valsartan and Sacubitril in Rat Plasma

N Anjaneyulu, R Naga Kishore, M Ravi Kumar and G Sneha
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G Sneha: Department of Pharmaceutical Analysis, Geethanjali College of Pharmacy, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 6, issue 5, 105-110

Abstract: A basic precise selective, sensitive isocratic technique was developed and valid for the quantitative synchronic estimation of Sacubitril and Valsartan drug in rat plasma was by RP- HPLC system. The chromatographic activity separation was administrated out on Intersil C18 (250 x 4.6mm, 5μm) column with a mix of acetonitrile: di-potassium hydrogen phosphate, pH 3.0 adjusted with Phosphate buffer (30:70%v/v) as mobile part. The analytes were eluted with a rate of flow of 0.8ml/min and at a wavelength of 371nm of UV detection. The strategy was valid for precision, accuracy, linearity, Limit of detection, Limit of Quantification, Ruggedness following the ICH guidelines.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:6:y:2018:i:5:p:105-110

DOI: 10.19080/GJPPS.2018.06.555697

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